A satirical inversion of the ideal of the perfect American nuclear family, they are an eccentric wealthy family who delight in everything grotesque and macabre, and are never really aware that people find them bizarre or frightening. In fact, they themselves are often terrified by "normal" people.

In Oklahoma in the 1920s, Rubin Flood loses his job as a traveling salesman when the company goes bankrupt. This adds to his worries at home. His wife Cora is frigid because of trying to make ends meet. His teenage daughter Reenie is afraid of going out on dates, but eventually makes friends with a troubled Jewish boy Sammy Golden, and his son is a mama's boy. He finally storms out of the house when Cora falsely accuses him of having an affair with Mavis Pruitt.

Danny Thomas, an entertainer, tries to balance his home life with the needs of his career, with hilarious results.

Andy gets into hot water because of his frequent lodge meetings.