Following the success of the three-part miniseries of the same name, the drama series follows the daily lives of Seattle's Gardner family. Joe Gardner is the owner of a successful plastics business and the father of four adult children. The Gardner family includes twice-divorced daughter Anne, who returns home with her two teenaged children; daughter Lindley and husband Jim, parents of a newborn baby daughter; black sheep son Jack; and conservative youngest son Sam, newly married to free-spirited Kay.

Andie is an outcast, hanging out either with her older boss, who owns the record store where she works, or her quirky high school classmate Duckie, who has a crush on her. When one of the rich and popular kids at school, Blane, asks Andie out, it seems too good to be true. As Andie starts falling for Blane, she begins to realize that dating someone from a different social sphere is not easy.

When a shy teenager's new-found powers help him score at basketball - and with the popular girls - he has some pretty hairy decisions to make.