At Oceanfront High School, female students are being targeted by an unknown serial killer. Meanwhile, a married teacher hides his flings with nubile students, and an awkward male is frustrated by the plethora of uninhibited freewheeling young girls.

When men on a photo safari stumble into a misanthropic doctor’s remote camp with a wounded comrade, the doctor's restless wife supplements her usual pursuit (voodoo, especially as a way to off her husband) with a new one: seduction. As men lose their hearts (sometimes literally) to the alluring voodoo priestess, she embarks on a killing spree that turns the jungle blood red.

Deep in the jungles a mad scientist is using the natives' voodoo for his experiments to create an indestructible being to serve his will. When a party of gold seekers stumbles upon his village, the scientist realizes that Marilyn the expedition's evil leader is the perfect subject for his work.

Ellen Burton arrives in Africa to join Dr. Mary as her nurse, bringing modern medicine to the native peoples. Lonni Douglas, an animal wrangler and fortune hunter, agrees to take her upriver, despite his misgivings about her suitability for Africa. They battle escaped gorillas, hostile natives, infected lion wounds, and hostile witch doctors to reach their destination and on the way, they fall in love. Will their contrasting interests doom their romance?