An intimate biopic of Pedro Zamora, an HIV-positive Cuban-American, who was cast for the MTV reality show, The Real World: San Francisco, in 1994. Due to his experience on the Real World, Pedro became a celebrity and a sympathetic face of the AIDS epidemic for millions of Americans who had never met anyone with HIV/AIDS.

The casts of the first four "Real World" seasons reunite to relive old times, settle feuds, and answer questions from a studio audience.

Each year, seven strangers in their twenties, from different backgrounds and countries, are chosen to come live together in a major city.