In Arizona in the late 1800s, infamous outlaw Ben Wade and his vicious gang of thieves and murderers have plagued the Southern Railroad. When Wade is captured, Civil War veteran Dan Evans, struggling to survive on his drought-plagued ranch, volunteers to deliver him alive to the "3:10 to Yuma", a train that will take the killer to trial.

Alice and her friends plan to make it rich by robbing an armoured truck, but everything goes haywire when Alice is shot. She wakes up from a year-long coma to find herself down the rabbit hole in a world of pimps, pushers and police payoffs.