Follow the investigations of a team of NYPD forensic scientists and police officers identified as "Crime Scene Investigators".

Trapped in their New York brownstone's panic room, a hidden chamber built as a sanctuary in the event of break-ins, newly divorced Meg Altman and her young daughter Sarah play a deadly game of cat-and-mouse with three intruders - Burnham, Raoul and Junior - during a brutal home invasion. But the room itself is the focal point because what the intruders really want is inside it.

Two homicide detectives are on a desperate hunt for a serial killer whose crimes are based on the "seven deadly sins" in this dark and haunting film that takes viewers from the tortured remains of one victim to the next. The seasoned Det. Sommerset researches each sin in an effort to get inside the killer's mind, while his novice partner, Mills, scoffs at his efforts to unravel the case.