Quinn Forte had it all: power, money, a brother who idolized him, and a woman who loved him. He also had enemies. In the course of one night, he loses everything. Betrayed by someone in his inner circle, Quinn is set up and arrested. His father, the patriarch of the criminal empire is killed and his brother suspects that Quinn is behind it all. When he's released from jail he tries to escape the demons from his past, but that becomes an impossible task. Campbell, the ruthless new leader of "The Company" won't let him leave in peace. So instead of escaping them, Quinn fights back. He joins forces with his former henchman and friend, The Swede, and takes on his enemies head on.

Raymond "Red" Reddington, one of the FBI's most wanted fugitives, surrenders in person at FBI Headquarters in Washington, D.C. He claims that he and the FBI have the same interests: bringing down dangerous criminals and terrorists. In the last two decades, he's made a list of criminals and terrorists that matter the most but the FBI cannot find because it does not know they exist. Reddington calls this "The Blacklist". Reddington will co-operate, but insists that he will speak only to Elizabeth Keen, a rookie FBI profiler.

When Buy More computer geek Chuck Bartowski unwittingly downloads a database of government information and deadly fighting skills into his head, he becomes the CIA's most vital secret. This sets Chuck on a path to become a full-fledged spy.

From murder and espionage to terrorism and stolen submarines, a team of special agents investigates any crime that has a shred of evidence connected to Navy and Marine Corps personnel, regardless of rank or position.