Around the year 1500, the Italian priest Don Filippo Neri helps street kids and orphans in his poor little chapel.

Fr. Hugh O'Flaherty is a Vatican official in 1943-45 who has been hiding downed pilots, escaped prisoners of war, and Italian resistance families. His activities become so large that the Nazis decide to assassinate him the next time he leaves the Vatican.

A pair of twins, Anna and Tony, leave their country to go to Rome to make their fortune. Anna knows how to sing and Tony knows how to dance. They suffer many setbacks, but they are willing to go the distance in order to succeed.