Scooby-Doo and the Mystery, Inc. gang are launched into the 21st century, with new mysteries to solve.

Welcome to Eltingville takes place in Eltingville, Staten Island, and focuses on the lives of four teenage boys: Bill Dickey, Josh Levy, Pete DiNunzio and Jerry Stokes, all members of "The Eltingville Club", who have shared interests in comic books and science fiction, among other things.

During the mid-22nd century, a century before Captain Kirk's five-year mission, Jonathan Archer captains the United Earth ship Enterprise during the early years of Starfleet, leading up to the Earth-Romulan War and the formation of the Federation.

Jerri Blank is a former prostitute and junkie whore who returns to high school as a 46-year-old freshman at Flatpoint High. Jerri ran away from home and became 'a boozer, a user, and a loser' after dropping out as a teenager, supporting her drug habits through prostitution, stripping, and larceny. She has been to prison several times, the last time because she 'stole the TV'. At home, Jerri's father Guy is comatose, although he seems perfectly capable of amazing feats. Her stepmother Sara is vain and bitter, and stepbrother Derrick is a bullying jock. Jerri tries to do things the right way but always ends up learning the wrong lesson. Her hijinks often involve, either directly or indirectly, neurotic history teacher Chuck Noblet and his secret lover, sensitive art teacher Geoffrey Jellineck.

When 25-year-old New Yorker Eric Traber gets fired from his job and kicked out of his apartment, he fears the worst. But his best friend, Ziggy, shows up A.W.O.L. from the Peace Corps and leads him out to the swank Hamptons for Easter weekend in search of betterment and understanding. Once there, they confront the adult roles of life for the first time; fraud, attempted murder, two-faced disloyalty and well-catered cocktail parties!

Big Pete puts aside his pride to help Little Pete break the record for the number of houses visited on Halloween.