The title characters of the series are a family of machine-enhanced human beings possessing unique powers after being augmented with bionic technology, much like The Six Million Dollar Man and The Bionic Woman. Each family member is given specific bionic powers, and thus they form a superhero team named Bionic Six.

While attending prep school at Warfield Academy, James Bond Jr. with the help of his friends I.Q. (supposedly the grandson of Q) and Gordo Leiter (supposedly the son of Felix Leiter), fights against the evil terrorist organization SCUM (Saboteurs and Criminals United in Mayhem). Expanding on his uncle's famous line, James Bond Jr.'s catch phrase was "Bond, James Bond. Junior."

Using a holographic computer she inherited from her father, Jerrica Benton turns herself and her pals into pop-music group Jem and the Holograms.

A probationary angel is sent back to Earth to team up with an ex-cop and help people.