A city slicker's wife is killed in the backyard of their new country home, and he claims that Bigfoot did it. When he's arrested for her murder, he spends his last free weekend with his misfit friends trying to track down the creature.

After Portland homicide detective Nick Burkhardt discovers he's descended from an elite line of criminal profilers known as "Grimms," he increasingly finds his responsibilities as a detective at odds with his new responsibilities as a Grimm.

Tate Noble returns to the town of his youth where as a boy his parents were murdered. His childhood friend Samuel, now the sheriff of La Mesa knows who is responsible, and Tate's arrival sparks hostility between Samuel and his father Judge Carter. As the mystery unravels, Tate and Samuel enlist help from an unlikely source, the mob, in order to bring to justice the man ultimately responsible, the evil Harcourt Simms.

Follow the investigations of a team of NYPD forensic scientists and police officers identified as "Crime Scene Investigators".