After losing his wife of 28 years in a skiing accident, widower Lou Chadway (Hal Linden) falls for and marries his daughter's sexy roommate but soon learns that he has absolutely nothing in common with her. Peg Gilford (Anne Meara) is a divorced grandmother who comes along to take Lou's mind off her and they embark on a secret love affair.

During an experiment gone bad, radiation turns a scientist into a raging green behemoth whenever he becomes agitated. Unable to control his transformations, David Banner searches for a cure as he crosses the country, fugitive-style, with a dogged tabloid reporter on his trail.