Meet Spot, a clever little dog with big dreams of becoming a real boy. When Spot finds out that a crazy scientist can make his wish come true, he takes a cross-country trek with Leonard, his best friend and master, and their mom. However, Dr. Krank's experiments are a little less than perfect, and it will take Leonard and his pet pals to right this genetic wrong.

Brad Sexton and his wife, Caroline, are wealthy New Yorkers with both marital and financial problems. The latter issue becomes a pressing matter when they discover that their accountant has embezzled millions and pinned the blame on them. Forced to go on the lam, Brad and Caroline end up in an Amish area of Pennsylvania and decide to pose as members of the religious group to evade the IRS. As the two adapt to the simple Amish lifestyle, they begin to reconnect.