Due to a genetic disorder, handsome librarian Henry DeTamble involuntarily zips through time, appearing at various moments in the life of his true love, the beautiful artist Clare Abshire.

Though Bobby Stevens appears to be a regular family man with a nine-to-five job, he's actually an expert thief who is seeking a few last big jobs so he can finally leave the business for a comfortable, lawful lifestyle with his wife, Hope, and their two children. While they never discuss Bobby's illegal pursuits, Hope is growing weary of turning a blind eye.

A married workaholic, Michael Newman doesn't have time for his wife and children, not if he's to impress his ungrateful boss and earn a well-deserved promotion. So when he meets Morty, a loopy sales clerk, he gets the answer to his prayers: a magical remote that allows him to bypass life's little distractions with increasingly hysterical results.

Newlywed Melinda Gordon tries to help the dead communicate with loved ones, but sometimes the messages she receives are intense and confusing. Most of Melinda's efforts involve resolving conflicts that are preventing the spirits from passing over.

When petty criminal Earl Hickey wins the lottery, he sets off on a quest to repair his questionable karma.

ER explores the inner workings of an urban teaching hospital and the critical issues faced by the dedicated physicians and staff of its overburdened emergency room.