An anthology series centered around some of history's most famous criminal investigations.

A formerly blacklisted spy uses his unique skills and training to help people in desperate situations.

A case involving drug lords and murder in South Florida takes a personal turn for undercover detectives Sonny Crockett and Ricardo Tubbs. Unorthodox Crockett gets involved romantically with the Chinese-Cuban wife of a trafficker of arms and drugs, while Tubbs deals with an assault on those he loves.

Presented by Walsh, the show profiles and assist law enforcement in the apprehension of fugitives wanted for numerous crimes, including murder, rape, kidnapping, child molestation, white-collar crime, organized crime, armed robbery, gang violence, and terrorism, and also many of whom are currently on the FBI Ten Most Wanted Fugitives list.