A secretary's life changes in unexpected ways after her dog dies.

Tim and Eric Awesome Show, Great Job! is an American sketch comedy television series, created by and starring Tim Heidecker and Eric Wareheim, which premiered February 11, 2007 on Cartoon Network's Adult Swim comedy block and ran until May 2010. The program features surrealistic and often satirical humor, public-access television–style musical acts, bizarre faux-commercials, and editing and special effects chosen to make the show appear camp. The program featured a wide range of actors, spanning from stars such as Will Ferrell, John C. Reilly, David Cross, Bob Odenkirk, Will Forte and Zach Galifianakis, to alternative comedians like Neil Hamburger, to television actors like Alan Thicke, celebrity look-alikes and impressionists. The creators of the show have described it as "the nightmare version of television."

After the death of his wife, world-class neurosurgeon Dr. Andrew Brown leaves Manhattan and moves his family to the small town of Everwood, Colorado. There he becomes a small-town doctor and learns parenting on the fly as he raises his talented but resentful 15-year-old son Ephram and his 9-year-old daughter Delia.