15 years after of its breakdown, a music band have a second chance of exit.

In the Headquarters of the T.I.A. (Terminal Intelligence Agency), someone has stolen Professor Bacterio's most dangerous invention, the D.O.T. (Demoralizer of Troops), an artifact that ends up in the hands of a very short, wacky dictator who is ready to use it for criminal purposes. The T.I.A Chief, though, is firm in his resolve: if he wants to get the D.O.T. back, he must NOT count on his agents Mortadelo & Filemon. But when the crime fighting duo discover that the T.I.A. has engaged a cocky and slimy detective from outside the agency, they decide to act at their own risk, even if that risk involves all of Humanity.

Lucas Santos, named El Santo is petty thief going continuously in and out of jail. Tired of small thefts, he aims to strike a blow that makes him famous and become the star of all media. His wife Lucia, a comprehensive and sweet woman, while awaiting the return of her husband, works as a stripper at a nightclub. Finally, Lucas gathers a band of petty thieves and decides to steal, from the National Museum of Art Reina Sofía, its most valuable painting: Picasso's Guernica.

Beldar and Sonja, a pair of thieves, steal a precious gem from the crypt of the Order of the Thousand Eyes, a daring act that will lead to unforeseen consequences.

Wafer factory-owner P. Tinto and his wife Olivia want a child of their own more than anything else in the world. Years of trying, however, have left them with nothing but a pair of extraterrestrial midgets living in the spare bedroom. When they decide to try adoption, a series of misroutings and chance encounters results in an escaped adult mental patient arriving at their door with adoption papers in hand. P. Tinto and Olivia accept this without question and welcome him in as their son. Can this family arrangement work?