Friends and family members nominate a candidate that they consider poorly dressed and ask the show to make over the "fashion victim." Fashion Police Stacy London and her partner ambush the candidate and make them an offer-- they are given a $5000.00 budget for a new wardrobe, which they must purchase in New York City boutiques over the course of two days, but only on the condition that they allow Stacy & her partner to critique, and in most cases throw out, their existing wardrobe.

As a child, Frank McKlusky watched his daredevil father "Madman" McKlusky become comatose in an ill-fated motorcycle stunt. Now as a risk-avoiding adult, he lives with his parents and always wears protective gear. When he suspiciously loses his partner on the job, Frank must become a master of disguise, take a sexy new partner and grab evidence to bust up the biggest insurance scam going!

The Stevens are a middle-class family living in Sacramento, CA. Husband and father Steve is a successful attorney. Wife and mother Eileen is a state Senator. Their oldest child Donnie ia a high-school sports legend. Ren, an 8th-grader, is just about the perfect daughter. She makes the best grades, she's popular, she does volunteer work and other extracurricular tasks by the score. Her brother Louis, in the 7th grade, is her opposite. He likes to sleep late, he's messy, his grades are not good, he's frequently in detention and he seems to take nothing seriously. But he is serious about finding something of his own that he can do to put himself on a par with the rest of his overachieving family. Though he and Ren occasionally soften their attitudes toward each other, at any given moment the're likely to be fighting like mongoose and cobra.

Ray Barone is a successful sportswriter living on Long Island with his wife Debra, daughter Ally, and twin sons, Geoffrey and Michael. That's the good news. The bad news? Ray's meddling parents, Frank and Marie, live directly across the street and embrace the motto "Su casa es mi casa," infiltrating their son's home to an extent unparalleled in television history.