The TARDIS materialises in Paris in the year 1572 and the Doctor decides to visit the famous apothecary Charles Preslin. Steven, meanwhile, is befriended by a group of Huguenots from the household of the Protestant Admiral de Coligny. Having rescued a young serving girl, Anne Chaplet, from some pursuing guards, the Huguenots gain their first inkling of a heinous plan being hatched at the command of the Catholic Queen Mother, Catherine de Medici.

The TARDIS crew lands in the Himalayas of Cathay in 1289, their ship badly damaged, and are picked up by Marco Polo's caravan on its way along the fabled Silk Road to see the Emperor Kublai Khan. The story concerns the Doctor and his companions' attempts to thwart the machinations of Tegana, who attempts to sabotage the caravan along its travels through the Pamir Plateau and across the treacherous Gobi Desert, and ultimately to assassinate Kublai Khan in Peking, at the height of his imperial power.

The adventures of The Doctor, a time-traveling humanoid alien known as a Time Lord. He explores the universe in his TARDIS, a sentient time-traveling spaceship. Its exterior appears as a blue British police box, which was a common sight in Britain in 1963 when the series first aired. Along with a succession of companions, The Doctor faces a variety of foes while working to save civilizations, help ordinary people, and right many wrongs.

Barbara Wright and Ian Chesterton, two humble teachers during 1963, discover a genius student's grandfather, simply known as "the Doctor", and his police box time machine. Deciding that the pair knows too much about his otherworldly origins, they are whisked away on a journey through time and space.