Each Challenge pits numerous cast members from past seasons of reality shows against each other, dividing them into two separate teams according to different criteria, such as gender, which show they first appeared on, whether or not they're veterans or rookies on the show, etc. The two teams compete in numerous missions in order to win prizes and advance in the overall game.

"Road Rules" documents the lives of five to six strangers as a mysterious voice sends them across various regions of the world, tackling a series of adventures. If they can successfully make it to the end of the adventure, they will receive a handsome reward.