The secret US abduction of a suspected terrorist from his Middle East homeland leads to a wave of terrorist attacks in New York. An FBI senior agent and his team attempt to locate and decommission the enemy cells, but must also deal with an Army General gone rogue and a female CIA agent of uncertain loyalties.

Murphy Brown (Candice Bergen) is a recovering alcoholic who returns to the fictional newsmagazine FYI for the first time following a stay at the Betty Ford Clinic residential treatment center. Over 40 and single, she is sharp tongued and hard as nails. In her profession, she is considered one of the boys, having shattered many glass ceilings encountered during her career. Dominating the FYI news magazine, she is portrayed as one of America's hardest-hitting (though not the warmest or more sympathetic) media personalities.