Can you tell the difference between fact and fiction? Several stories of strange, mysterious and incredible occurrences are chronicled during each episode. It is up to the viewer to decide which stories actually happened and which were completely fabricated by the show’s writers. The answer is revealed by Jonathan Frakes at the conclusion of each episode.

When shrimp from Mexico, tainted with Cholera, is served to people on a plane bound for LA, an outbreak ensues. A doctor sets out to find the source and contain it before it turns into an epidemic. And if things weren't bad enough, a drug mule from the plane, who was smuggling cocaine in his stomach, infects the drugs, which will be on the streets soon. And to top things off, her husband who is on a camping trip with their two children is sick but did not show any symptoms until they were isolated from the rest of the world. Can she get to them in time?

The exploits of FBI Special Agents Fox Mulder and Dana Scully who investigate X-Files: marginalized, unsolved cases involving paranormal phenomena. Mulder believes in the existence of aliens and the paranormal while Scully, a skeptic, is assigned to make scientific analyses of Mulder's discoveries that debunk Mulder's work and thus return him to mainstream cases.

Duncan MacLeod cannot die -- he is a 400-year-old immortal, who has seen his share of humanity's history. Still, he risks his life in battle against other immortals and tries to save people from harm.