Deputy Police Chief Brenda Leigh Johnson transfers from Atlanta to LA to head up a special unit of the LAPD that handles sensitive, high-profile murder cases. Johnson's quirky personality and hard-nosed approach often rubs her colleagues the wrong way, but her reputation as one of the world's best interrogator eventually wins over even her toughest critics.

A young man receives an emergency phone call on his cell phone from an older woman. She claims to have been kidnapped – and the kidnappers have targeted her husband and child next.

In the unreal world of Sacred Heart Hospital, John "J.D." Dorian learns the ways of medicine, friendship and life.

After surviving a stabbing by a student, teacher Trevor Garfield moves from New York to Los Angeles. There, he resumes teaching as a substitute teacher. The education system, where violent bullies control the classrooms and the administration is afraid of lawsuits, slowly drives Garfield mad.

ER explores the inner workings of an urban teaching hospital and the critical issues faced by the dedicated physicians and staff of its overburdened emergency room.

The exploits of FBI Special Agents Fox Mulder and Dana Scully who investigate X-Files: marginalized, unsolved cases involving paranormal phenomena. Mulder believes in the existence of aliens and the paranormal while Scully, a skeptic, is assigned to make scientific analyses of Mulder's discoveries that debunk Mulder's work and thus return him to mainstream cases.