Harley Quinn joins forces with a singer, an assassin and a police detective to help a young girl who had a hit placed on her after she stole a rare diamond from a crime lord.

Leaving their troubles in Brooklyn behind, best friends Matt and Vincent head to Miami for adventure, hoping to find Matt's old flame, up-and-coming fashion model Arielle. Diving into the glamorous local scene at the Hotel Soleil's hip club Nocturnal, they uncovers the dangerous and possibly seedy underbelly of South Beach.