After being released from prison, a man known as The Rambler stumbles upon a strange mystery as he attempts a dangerous journey through treacherous back roads and small towns en route to reconnecting with his long lost brother.

Frederick Abberline is an opium-huffing inspector from Scotland Yard who falls for one of Jack the Ripper's prostitute targets in this Hughes brothers adaption of a graphic novel that posits the Ripper's true identity.