In California, Maria has awful nightmares and visions of her sister who committed suicide one year ago. Her roommate Chris invites Maria to travel with her and her friends Tanya and Rose on vacation to her uncle's house in Saguaro, Arizona, to relax. When the group arrives in the house, they immediately go to a night-club to have fun and chase some local guys for sex; however, the evil El Charro is seeking Maria, killing her friends with his machete.

On a bet, a gridiron hero at John Hughes High School sets out to turn a bespectacled plain Jane into a beautiful and popular prom queen in this outrageous send-up of the teen movies of the 1980s and '90s.

Detectives Nick O'Malley and Kate Benson work in Special Unit 2, a secret precinct of the Chicago Police Department whose sole charge is to protect the city's citizens from Links, a malicious paranormal species that is the missing link between man and beast.