Dr. Temperance Brennan and her colleagues at the Jeffersonian's Medico-Legal Lab assist Special Agent Seeley Booth with murder investigations when the remains are so badly decomposed, burned or destroyed that the standard identification methods are useless.

One night Nancy Lyon awakes in pain and dies shortly after - poisoned with arsenic. Her family immediately suspects her husband Richard, who left her temporarily the year before because of an affair. Especially Nancy's brother is keen on getting the children away from the suspected murderer. All evidence points against Richard, but in court Richard surprisingly presents proof that his wife had depressions and maybe killed herself - or are these proofs just fake? -- Depicts an authentic case.