The pioneering trail to Oregon was littered with constant danger. Yet, the hope of the "promised land" keeps American families westward bound despite overwhelming odds. A calm, clear-thinking pioneer attempts to lead a wagon train through territory occupied by Pawnees and Sioux. Along the way, the hardy settlers face horse thieves, kidnappers, and unpredictable Indian attacks in their push to establish a new life in the rugged West.

Brave Eagle is a 26-episode half-hour western television series which aired on CBS from September 28, 1955, to March 14, 1956, with rebroadcasts continuing until June 6. Keith Larsen, who was of Norwegian descent, starred as Brave Eagle, a peaceful young Cheyenne chief. The program was unconventional in that it ⁕ reflects the Native American viewpoint in the settlement of the American West and ⁕ was the first series to feature an American Indian as a lead character. Larsen's co-stars were Kim Winona, a Sioux Indian, as Morning Star, Brave Eagle's romantic interest; Anthony Numkena of Arizona, a Hopi Indian then using the stage name Keena Nomkeena, appeared as Keena, the adopted son of Brave Eagle; Pat Hogan as Black Cloud, and Bert Wheeler of the comedy team Wheeler & Woolsey, as the halfbreed Smokey Joe, full of tribal tall tales but accompanying wisdom. The episodes center upon routine activities among the Cheyenne, clashes with other tribes, attempts to prevent war, encroachment from white settlers, racial prejudice, and a threat of smallpox.

Julia Garth, a female doctor, plans to introduce modern techniques of medicine to old Santa Fe in 1880, but is opposed by an established doctor, Rourke O'Brien.

A fugitive in British Burma hides on a tea plantation, thanks to a mutual attraction with owner Gwen Moore.

A crooked salmon fisherman tries to steal his best friend's fiancée and put him out of business.

Duncan MacDonald, a 19th-century Royal Canadian Mountie, has to escort a group of Cree Indians back to their above-the-border reservation. His guide in this endeavor is the not-too-trustworthy half-breed Natayo.