Former radio singer Kay learns from her gossipy friends that her husband, Steve, has had an affair with chorus girl Crystal. Devastated, Kay tries to ignore the information, but when Crystal performs one of her musical numbers at a charity benefit, she breaks down and goes to Reno to file for divorce. However, when she hears that gold-digging Crystal is making Steve unhappy, Kay resolves to get her husband back. The Opposite Sex is a remake of the 1939 comedy The Women.

The Ed Sullivan Show is an American TV variety show that originally ran on CBS from Sunday June 20, 1948 to Sunday June 6, 1971, and was hosted by New York entertainment columnist Ed Sullivan. It was replaced in September 1971 by the CBS Sunday Night Movie, which ran only one season and was eventually replaced by other shows. In 2002, The Ed Sullivan Show was ranked #15 on TV Guide's 50 Greatest TV Shows of All Time.