A doctor in 1890 England, in order to cure his wife's "sick mind," injects her with snake venom. She later gives birth to a daughter whom the villagers call "The Devil's Baby" and in a fit of fear they end up burning the family's house down. Years later a Scotland Yard detective is sent to the village to investigate a rash of deaths that are caused by snakebite.

In 25 AD, Judah Ben-Hur, a Jew in ancient Judea, opposes the occupying Roman empire. Falsely accused by a Roman childhood friend-turned-overlord of trying to kill the Roman governor, he is put into slavery and his mother and sister are taken away as prisoners.