Medical student Ted Grey graduates at the top of his class and quickly joins an elite pathology program, whose top students invite him into their circle. There he uncovers a gruesome secret: They play a game in which one tries to commit the perfect, undetectable murder, then the others compete to determine the victim's cause of death.

Molly Stewart is now a successful freelance photographer in New York, and after seeing a familiar woman at an art gallery, begins to suspect that she might be her long missing mother. Following her trail to Los Angeles, Molly finds herself in the center of a major crime syndicate who will stop at nothing to execute their diabolical plans.

New York journalist visits her distant cousin for the first time to write an article about her hard life in the bayous of Louisiana. Journalist's wild drug addicted daughter just adds to tensions between two families' cultures.