Using footage left over from Nemesis 2 and a very thin story line sees Alex again fighting the cyborg mercenaries in 1998 East Africa. This time, Alex finds that she has 20 half sisters who are waiting for her to return to 2077. Central Command wants Alex captured alive and scanned to see if her DNA is a strong and more powerful strain than the normal. But Alex may be too tough for Farnsworth to capture.

It has been 73 years since Alex failed and the Humans lost the Cyborg Wars. Since then, the Humans have been enslaved. Scientists have developed a new DNA strain, which could signal the end of the Cyborgs, and they inject it into a volunteer. When the Cyborgs learn of the woman and the baby they list both for termination.