The Blind Man has been hiding out for several years in an isolated cabin and has taken in and raised a young girl orphaned from a devastating house fire. Their quiet life together is shattered when a group of criminals kidnap the girl, forcing the Blind Man to leave his safe haven to save her.

Rose LeNoire is trying to hide her own dark secret as she and her companion, Jonathan Canus, hunt the vampire clan that killed her family. The two find themselves at a NYC college racing to kill the vampires before they can breed and increase their numbers.