The events of the film are based on the real facts of the Pacific War, when in June 1944 the American troops began landing on the Saipan island. On July 7, an order comes that everyone must die in order not to be captured by the enemy.

The critical establishment was clearly not prepared to accept a woman's prison film featuring former prostitutes recovering from venereal diseases, unwanted pregnancies, and estranged lovers. With its cat fights, hysterical tantrums, film noir lighting, and dramatic music, White Beast is indicative of the new influences of the Hollywood psychological thriller on Naruse. Caged (John Cromwell, 1950) initiated a cycle of women's prison movies in the United States that may or may not have been shown in Japan, but the stylistics of White Beast draw on the same paranoid woman's films and film noir conventions that preceded the American cycle.

Three bank robbers, Eijima, Nojiri, and Takasugi, flee the police and escape into the mountains. At an inn high in the Japanese Alps, Eijima and Nojiri encounter a young woman and her father, as well as Honda, a mountaineer. The inn folk do not realize their guests are wanted criminals and the visitors are treated with great kindness. Honda volunteers to lead them over the mountains, but Eijima's paranoia endangers all of them as they make the perilous trip.