In the 1840s, Ramsey MacKay, the driver for the struggling Wells Fargo mail and freight company, will secure an important contract if he delivers fresh oysters to Buffalo from New York City. When he rescues Justine Pryor and her mother, who are stranded in a broken wagon on his route, he doesn't let them slow him down and gives the ladies an exhilirating ride into Buffalo. He arrives in time to obtain the contract and is then sent by company president Henry Wells to St. Louis to establish a branch office.

A trio of American crooks board a ship bound for Europe, intending to get rid of $100,000 in stolen dough. With detective John Wade breathing down their necks, the crooks stash the loot in the trunk belonging to vacationing schoolmarm Mary Smith.

The "Caliban-Ariel" romance of fiftysomething John Barrymore and teenager Elaine Barrie is spoofed in this delightful 20th Century Fox musical. Adolphe Menjou plays the Barrymore counterpart, a loose-living movie star with a penchant for wine, women, and more wine. Alice Faye plays a nightclub singer hungry for publicity. Her agent (Gregory Ratoff) arranges a "romance" between Faye and Menjou. Eventually Faye winds up with Michael Whalen, allowing Menjou to continue his blissful, bibulous bachelorhood. Sing, Baby, Sing represented the feature-film debut of the Ritz Brothers, who are in top form in their specialty numbers--and who are awarded a final curtain call after the "The End" title, just so the audience won't forget them (The same device was used to introduce British actor George Sanders in Fox's Lancer Spy [37]).

In mid-nineteenth century England the medical establishment does not recognize the value of skilled nurses, cleanliness, nutrition and kindness. Florence Nightingale's heroic measures slowly changes all of this.

Aspiring Producer Michael McCreigh convinces Uncle Carlton to finance a play on the condition that he lives the play's ridiculous plot. If Michael fails, he must work in Carlton's meat packing plant.

An eccentric, wealthy spinster, 'Queenie' Baxter is erroneously presumed to be kidnapped. She subsequently pretends to indeed be kidnapped, , in order to allow a reward of $50,000 to benefit an impecunious family headed by Tony Orsatti and his three sons, Blackie, Doc and Flash.