The residents of Harker Heights suspect something is not quite right with their homeowners association.

ZOMBEX tells the story of a post-Katrina New Orleans as it deals with a new disaster, a zombie apocalypse. NOLA residents are no longer experiencing the depression and post-traumatic stress due to the trauma of the hurricane, thanks to the revolutionary ZOMBEX - a rogue, yet, "clinically-proven" anti-depressant pharmaceutical manufactured by a nefarious organization. For those who call the Big Easy their home, everything is just now turning around for them. Or, could it just be the drug, ZOMBEX, talking... Just as things are turning around for the city and its people, they once again must face a disaster of epic proportions. Only this time, they're dealing with the prospect of losing the people of New Orleans as they turn into the city's walking dead.

Chrissie and her friends set out on a road trip for a final fling before one is shipped off to Vietnam. Along the way, bikers harass the foursome and cause an accident that throws Chrissie from the vehicle. The lawman who arrives on the scene kills one of the bikers and brings Chrissie's friends to the Hewitt homestead, where young Leatherface is learning the tools of terror.