Ray Ferrier is a divorced dockworker and less-than-perfect father. Soon after his ex-wife and her new husband drop off his teenage son and young daughter for a rare weekend visit, a strange and powerful lightning storm touches down.

In the fictional town of Neptune, California, student Veronica Mars progresses from high school to college while moonlighting as a private investigator under the tutelage of her detective father.

Somewhere in the middle of Texas, Ameet (Sunil Malhotra) and Saima (Lisa Ray) have a problem. They were perfectly happy avoiding each other until their parents set them up to get married. The reluctant couple decide to do whatever it takes to break off the engagement. After some very embarrassing efforts, they finally succeed in getting their parents to call off the wedding, only to realize they have another problem, they're in love! Meanwhile, Saima's father (Asrani), deciding that she's passed her expiration date, promises her to Ashol (Ismail Bashey)- a sleazy playboy.

Bruce Banner, a genetics researcher with a tragic past, suffers massive radiation exposure in his laboratory that causes him to transform into a raging green monster when he gets angry.

In the unreal world of Sacred Heart Hospital, John "J.D." Dorian learns the ways of medicine, friendship and life.