After saving the life of the President, two secret service agents - Myka Bering and Pete Lattimer - find themselves assigned to the top secret Warehouse 13. The Warehouse is a massive, top secret facility that houses dangerous and fantastical objects. Together, Pete and Myka along with fellow agents Claudia, Steve Jinks and Warehouse caretaker Artie, must recover artifacts from around the globe before they can cause catastrophic damage.

As the city is locked down under quarantine, Alice finds out that the people that died from the previous incident at the Umbrella Corporation have turned into zombies. She then joins a small band of elite soldiers, who are enlisted to rescue the missing daughter of the creator of the mutating T-virus. Once lack of luck and resources happen, they begin to wage an exhilarating battle to survive and escape before the Umbrella Corporation erases its experiment from the face of the earth.