As the city is locked down under quarantine, Alice finds out that the people that died from the previous incident at the Umbrella Corporation have turned into zombies. She then joins a small band of elite soldiers, who are enlisted to rescue the missing daughter of the creator of the mutating T-virus. Once lack of luck and resources happen, they begin to wage an exhilarating battle to survive and escape before the Umbrella Corporation erases its experiment from the face of the earth.

The world is a bleak desolate place where the people live in elevated cities. As the ground is uninhabitable, the citizens spend most of their lives wasting their time in virtual reality. Carver is a dream-breaker whose job is to enter the world of VR and fix what is wrong. And what is wrong is that his gal pal Dinah has been murdered in VR which should not be possible. But Carver soon finds that Dinah has constructed a transducer which allows people to enter VR without other equipment, but creates a rift. That rift causes people to enter VR, but also allows the creatures from the game to enter the real world.