Charlie's ex-wife disappears, and he goes to where she grew up--a rural town in the midwest--to look for her. But, surprisingly, nobody knows about her or any of her many relatives, the Newmans. He meets aliens; but when he contacts the FBI, they don't believe him. He tells his story to a tabloid; and suddenly, he is chased by the aliens.

When the teenagers in a small Illinois town start getting murdered, the police chief makes a connection to the mysterious scientific experiments being done at the local university and must stop them before his own son is dragged into the deadly scheme.