The Party Animal is a documentary-style comedy about a sex-starved man, Pondo Sinatra, a 26-year-old college student whom everyone agrees is doomed to die a virgin. Desperate to break what seems to be a cosmic curse, he tries ever more bizarre schemes to seduce one the sexy, scantily-clad women who seem to be everywhere, taunting him and enjoying his misery. Despite his best efforts, however, he is rejected everywhere, even at the local cathouse. When Pondo threatens to kill himself, Studley, his ladykilling best friend, tries to help him in his quest to "get him a little", as does Studley's mentor, a wise old janitor named Elbow.

Newly-widowed Mabel Lederer, who has psychic and mediumistic abilities, sells her house and belongings, changes her name, and moves to a new town. There she rents a room in a boarding house and holds a seance with the other tenants, with comical results.