In 2019, Lincoln Six-Echo is a resident of a seemingly "Utopian" but contained facility. Like all of the inhabitants of this carefully-controlled environment, Lincoln hopes to be chosen to go to The Island — reportedly the last uncontaminated location on the planet. But Lincoln soon discovers that everything about his existence is a lie.

Detectives Marcus Burnett and Mike Lowrey of the Miami Narcotics Task Force are tasked with stopping the flow of the drug ecstasy into Miami. They track the drugs to the whacked-out Cuban drug lord Johnny Tapia, who is also involved in a bloody war with Russian and Haitian mobsters. If that isn't bad enough, there's tension between the two detectives when Marcus discovers that playboy Mike is secretly romancing Marcus’ sister, Syd.