Sikes and Francisco are called in to a case when a mysterious young girl, who looks part Newcomer, part human, appears. Her huge, brutish counterpart tries to free her from the precinct, and their bizarre relationship turns out to be the result of a slaveship medical experiment. Meanwhile, Cathy and Matt are going to sex school, in preparation of becoming intimate, while Buck distresses his parents by his anti-human opinions.

ER explores the inner workings of an urban teaching hospital and the critical issues faced by the dedicated physicians and staff of its overburdened emergency room.

An estranged father and son are paroled from the same maximum-security prison with one unusual condition, they must become roommates. Their severed bonds are strained as the father battles to keep his son free from the lures of street life.