Overland mail riders Jack Mason and his pal, Porchy, learn that an Indian uprising is imminent because one of the tribe has been murdered by a gang of outlaws. The primary town of the mail route is also being used as a hideout and base of operations for a gang of counterfeiters led by Joe Polini. Jack and an undercover federal agent, Duke Evans, round up the counterfeiters and turn Polini over to the Indian Chief as the killer of the brave.

The night before his grandson, Tommy Grayson, a mechanic at the Midland Aircraft Corporation, is to marry Gail, a former showgirl, Major Matt Grayson, a war veteran and watchman at the plant, catches two men breaking into the machine shop. The men run, but the major shoots one of them.....

The Rancho Grande, a Texas border ranch, cut off from the law by a gang of outlaws led by ranch foreman Bart Lane, who is holding the elderly owner of the ranch, Sarah Burton, a prisoner. Tex Lowery, an undercover Texas Ranger, rescues Martha Williams, a nurse sent for by the ailing Sarah, from a stagecoach holdup by Lane's henchmen. He later convinces Laner that he is a wanted outlaw named Ed Carter, and gains entry to Rancho Grande. But the real Ed Carter shows up.

Ray Whitley and the other Lazy-Q cowhands break up a plot by Mrs. Pierce (Isabel La Mal) to have her son George (Sid Coke) acquire the ranch by marrying the owner's daughter (Jean Joyce).

Skipper Murphy is serving as trainer and inspiration for his brother Red Murphy training for a world championship title bout. Trouble comes for the Murphys when Red runs up against a gambling syndicate and is put on the spot to throw the fight.

A (rather shady?) private detective specializing in recovering highly insured items gets involved in recovering a stolen necklace. In the process also gets involved with a secretary at the insurance company.

Outlaws of Sonora is a 1938 American Western "Three Mesquiteers" B-movie directed by George Sherman.