Machines have taken over, but left humans thinking that they are still the ones in charge. The androids need humans because of the human brain fluid; without it the android brains can't work. Until the mad scientist finds out how to make this brain fluid artificially that is.

Following the adventures of a bunch of nobodies who get up to a whole lot of nothing in the fictional prairie town of Dog River, Saskatchewan, Corner Gas focuses on the life (or lack thereof) of Brent LeRoy, proprietor of a gas station that is the only stop for miles around and a hub of action on the Prairies.