A tough, brilliant senior resident guides an idealistic young doctor through his first day, pulling back the curtain on what really happens, both good and bad, in modern-day medicine.

Marcy Meyers is down on her luck. Faced with piling bills, the remnants of a failed marriage, and now an imminent home foreclosure, she has nowhere to turn but to the hope of a miracle. That miracle she finds in Shoot the Moon, a national game show that promises a one in a lifetime chance to win it all. But Marcy's faith in the show comes with a price. As her relationship with her daughter Alice is put to the test, the clock ticks towards a seemingly inescapable fate. Shoot the Moon tells the story of miracles and the extraordinary place they are found.

Single working mom Christine Campbell has just learned that her ex is dating a much younger woman with the same first name. To avoid any confusion, the new girlfriend is dubbed New Christine, which leaves her with the unfortunate nickname Old Christine.

Simon is an intelligent and privileged young man whose family expects him to become a Princeton graduate. Crying out for attention from his reserved and cool hearted family, Simon commits numerous petty crimes and is soon sent away to boarding school where he befriends a "Deadhead," adopts the "hippie" lifestyle and dabbles in many drugs in his search for acceptance.

Life’s good for deliveryman Doug Heffernan, until his newly widowed father-in-law, Arthur, moves in with him and his wife Carrie. Doug is no longer the king of his domain, and instead of having a big screen television in his recently renovated basement, he now has a crazy old man.