Army colonel Gabriele Moresco and twelve of his soldiers occupy a hospital in Sicily, Italy, taking every patient and doctor as hostages and giving an ultimatum to the government: if they won't admit their role in hiding proof of the use of depleted uranium in the Balkan Wars and the subsequent countless cases of cancer among Italian soldiers in 56 hours, all the hostages will be killed. Negotiator Paolo Manfredi is called to save the hostages, not knowing that his wife and daughter are among them.

At the end of the seventies the Red Brigades are plotting a new target to hit, the president of the Christian Democrats Aldo Moro. On 16 March 1978, the band of the Red Brigades went on the attack. The terrorists kidnap Aldo Moro and kill all the men in his escort.

Turi Leofonte is released from prison after eleven years and asks for the surviving members of his old security detail to escort him back in Sicily to get revenge on his former associates – something the authorities indulge to seize a large stash of Mafia money he claims to have access to.