An orphan girl lives with apparently kind uncle who turns out to be a murderer.

After having been framed by gamblers, Muggs is barred from riding in horse races. Snce he can no longer race, he takes up a collection so Ma Brown, who owns the horses won't have her stable foreclosed on. However, one of the gamblers involved in the frame falls for Ma Brwn's daughter, and decides to come clean and confess to the police about the frame. The other gamblers hear about it and set out to shut him up and discredit Muggs and Ma Brown once and for all.

The East Side Kids are pursued by killers seeking a stolen necklace.