Crystal is the lead dancer in her own Burlesque show, but she has other plans for her troupe on this tour. While visiting Crystal’s brother, the Burlesque girls start to be picked off one by one, and its anyone’s guess who will survive.

After dying during a gun fight, a bunch of gangsters have their spirits trapped inside panties. Ashley chants a magic spell for luck....but that very moment, a gun fight breaks out across town. The spirits of newly-dead jewel thieves are suddenly sucked back to Earth - right into the girls' panties! The girls are infested with something far more itchy than fleas. The gangster-spirits hop from panty to panty.... and burrow through the FireWire, infecting all the models. In the meantime, Guido - the only gangster that escaped, sets out to interrogate the ill-behaved Spirits in each model's panties to learn the whereabouts of the missing Queen Shockra Jewel. Will the girls be able to release the gangsters from their panties and live normal lives? Can they help find the priceless jewel? Time is running out as they try to defeat the Curse Of The Pink Panties.