In trouble with the local authorities, Mabel Simmons, notoriously known as Madea, is on the run from the law. With no place to turn, she moves in with her friend Bam who is recovering from surgery. Unbeknownst to Bam however, Madea is only using the "concerned friend" gag as a way to hide out from the police.

Madea's neighborhood takes a turn for the worse when a foster mother moves in with her unruly kids. Suspicious activity leads Madea to take justice into her own hands. With Aunt Bam by her side, Madea uses her unique wit and wisdom for unforgettable results.